What to choose - "Creon" or "Mezim"? Which is better, the difference, the instruction manual, the feedback
Loads on the digestive system associated withirrational eating, frequent overeating, the use of difficult to digest products, lead to malfunctions in the pancreas, and sometimes can cause its inflammation (pancreatitis). To restore the optimal functioning of the organ, modern medicine offers a number of enzyme-containing preparations, among which you can choose "Creon" or "Mezim". Which is better from these tools?
What other analogues exist and how to get the maximum therapeutic effect without overpaying for marketing tricks?
Composition of preparations containing pancreatin
The main active substance of fermentate-containingdrugs for the pancreas is pancreatin, which contains: lipase, which breaks down the fats that come with food; amylase, which deals with carbohydrate catabolism; protease, involved in the digestion of proteins. Most people who choose "Creon" or "Mezim" (which depends on each individual case) pay attention to the amount of pancreatin and additional components.
If a macrogol is a substance that has a lightlaxative action, is contained in both preparations, dimethicone, reducing gas formation, is present only in "Creon". Comparing the instructions for the use of these drugs, you can get a table, which reflects the concentration of the main substance and the dosage of the three enzymes.
Fermented preparations | Pancreatin, mg | Lipase, units | Protease, units | Amylase, units |
CREON 25000 | 300 | 25000 | 1000 | 18000 |
CREON 10000 | 150 | 10000 | 600 | 8000 |
Mezim Forte | minimum | 3500 | 250 | 4200 |
Mezim Forte 10000 | 137,5 | 10000 | 375 | 7500 |
Of the optional components in any modification"Creon" is available: liquid paraffin, macrogol 4000, dimethicone 1000 and polyethylene glycol. In the capsule shell is gelatin, as well as: titanium dioxide, yellow and red iron oxide. In tablets "Mezima" the manufacturer, in addition to the main substance, included: cellulose, magnesium stearate, silicon dioxide, sodium carboxymethyl starch. The soluble coating of each of these pills contains: simethicone emulsion, talc, macrogol 6000, titanium dioxide and azorubic varnish.
The role of enzymes in the human body and indications for their use
Enzymes, or digestive enzymes, helpthe body splits complex substances into simpler compounds. Starch is involved in the catabolism of carbohydrates; stapesin (lipase) dissolves and fractionates lipids (triglycerides), ensuring the delivery of fatty acids to various organs and tissues; proteases (or proteolytic enzymes) hydrolyse proteins, releasing amino acids. All these enzymes are synthesized by the pancreas. If a person has a deficiency in these digestive enzymes, the digestion of vitamins and minerals from food deteriorates, hormone production disorders occur, problems arise with the functioning of the gastrointestinal tract, the chair is broken, there are disruptions in the functioning of the pancreas and the risk of inflammation. The lack of enzymes can manifest itself with various symptoms: heartburn, belching, constipation or diarrhea. It can occur with a sharp change in diet (exit from the diet, eating exotic dishes on a trip, visiting a restaurant with a sample of delicious dishes). In such cases, "Creon 10000" or "Mezim" will help improve the well-being. Which is better depends on the severity of the condition.
If there is a slight malaise afterovereating or a drug is needed for prevention, then you can give preference to Mezima tablets. In case of serious digestive disorders, the doctor will prescribe capsules with a high dose of pancreatin ("Creon 25000").
Features of the mechanism of action of "Mezima" and other fermento-containing tablets
Mezim is an enzyme preparation thatcompensates for exocrine pancreatic dysfunction. It promotes the digestion of food when eating foods that cause gravity in the stomach and other problems due to malnutrition. Just like Creon, Mezim, Pancreatin (which it is better to choose from enzyme-containing drugs, the doctor advises) contain lipase, amylase and protease that break down fats, proteins and carbohydrates to fatty acids, monosaccharides, glycerol and amino acids .
The tablets covered with a cover, at reception it is impossiblechew or grind. They begin to dissolve already in the stomach, so the preparation gets into the 12-colon form in a modified form. Of the other drawbacks of the Mezim or Pancreatin tablets, one can note their uneven distribution along the food lump and a later penetration into the intestine. Therefore, in the issue of "Creon" or "Mezim", which is better for the doctor in the treatment of pancreatitis or pancreatic dysfunction of the patient, the answer is - the first drug. The duration of replacement therapy can range from several days to several months.
The main advantage of "Creon"
The main factor in choosing this medicineis its form of release. Thanks to the latest advances in medicine and pharmaceuticals, Creon, obtained by extracting and grinding pancreatin of animal origin (cattle or pigs), is encased in mini-microspheres 0.75-1.25 mm in diameter. They are placed inside the capsule, which, disintegrating in the gastric juice, releases them and allows them to continue their way through the digestive tract in their original form, not reacting to the aggressive environment of the stomach.
The action of the minimosphere begins induodenum, where they actively enter into the reaction of catabolism of fats, proteins and carbohydrates. Pros of microspheres also consist in the fact that pancreatin is evenly mixed with food and is better distributed according to the contents of the stomach. "Minishariki" with the medicine penetrate into the intestine much more quickly and dissolve only in its environment, thanks to the composition of its shell. In addition, the enzyme doses in Creon are much higher than in tablets of Mezima and other medications. It is available in three dosages: 10,000, 25,000 and 40,000. The first two kinds of "Creon" are dispensed from the pharmacy without a prescription, and the latter is intended solely for serious diseases, so it is mandatory to be prescribed by a doctor.
"Festal" is a combined analogue, what is the difference
This drug, like other digestive enzyme drugs, is aimed at normalizing the process of digestion and eliminating discomfort. It is made in the form of enteric dragees with pancreatin.
Choosing "Festal" or "Mezim" (which is better), or"Creon" - you need to take into account that the first drug is categorically contraindicated in acute pancreatitis or exacerbation of the chronic stage of the disease. This is due to the content in "Festal" (and also "Enzistale" and "Normoenzime") of additional ingredients - hemicellulose and bovine bile, which facilitates the emulsification and absorption of fats. Such drugs are not recommended for people suffering from hepatitis or bile duct disease.
What is better to give to children: Mezim or Creon
The instructions for use indicate that "Creon10000 "is prescribed for children with insufficient exocrine function of the pancreas, which is associated with gastrointestinal diseases caused by: chronic pancreatitis, cystic fibrosis, gastroectomy or surgery on the pancreas, Schwamman-Diamond syndrome, oncological and other ailments.
Of the most common diagnoses, withwhich doctors prescribe to the child "Creon 10000" (no more), you can identify dysbacteriosis (during complementary feeding) and lactose intolerance (lactase deficiency). In the question, "Creon" or "Mezim", which is better for children, experts prefer the minimrocrosphere, which helps to most accurately maintain the dosage by counting the "balls" depending on the weight of the baby's body. In addition, the medicine penetrates into the intestine, bypassing the aggressive environment of the stomach. For example, a child at the age of three months is assigned ¼ of the capsule, and in 1.5 years - about a third. Minimicrospheres are added to liquid food (not hot), they can be dissolved in beverages with sour taste (fruit juice or apple puree). For children who are exclusively breastfed, Creon is not prescribed, since water evaporation can damage the lactobacillus intestinal microflora of the baby, increasing the risk of growth of the population of putrefactive bacteria, and may also prevent the natural recovery of the baby's own pancreas.
Contraindications
Depending on the concentration of pancreatin,Enzyme drugs are successfully used in complex gastroenterological therapy. However, when choosing which is better, Mezim or Creon, it is necessary to remember that the appointment of both drugs is excluded in acute pancreatitis (inflammation of the pancreas), exacerbation of the chronic disease of this organ and individual intolerance of the basic or additional components of the drugs. It is undesirable to use enzyme-containing medicines independently. Only the doctor on the basis of the results of the survey reveals the stage of the development of the disease and prescribes the optimal drug in accordance with the patient's condition. Also it is not recommended to get carried away by the described means, taking them long and uncontrollably: this can provoke pancreas dysfunction, which will be unable to produce the necessary enzymes independently.
Reviews and advice from doctors
Despite the fact that the mechanism of action of "Creon" and"Mezima" is similar, choosing what is best, "Mezim" or "Creon" in pancreatitis, doctors take into account the various effects of these drugs on the body. It is due to the concentration of pancreatin and the dosage of the prescription, as well as the innovative technology of making German medicines in capsules ("Creon"). In most cases, to improve digestion and eliminate small negative symptoms in the pancreas after consuming fatty and spicy food, doctors consider it expedient to use Mezima forte. If such conditions occur occasionally, then such help for the pancreas can be provided independently.
If heartburn, bloating and other symptomsproblems in the functioning of the digestive tract become frequent, it is necessary to visit a doctor and undergo a survey. The doctor after familiarizing himself with the analysis will be able to determine exactly, "Creon" or "Mezim", which is better and more effective for individual therapy. It can be, as a short medical course of reception of capsules with a big dose of enzymes, and long symptomatic reception of the tablets facilitating work of a pancreas and normalizing function of digestion. Capsules are swallowed whole with a sufficient number of non-hot and not too acidic liquids (pH <5), since with the acid-base balance of the drink above 5, the shell of the microspheres is destroyed.
Which is better, "Creon" or "Mezim": difference (opinions of patients and young mothers)
Virtually everyone who happened to take these enzyme-containing drugs or give them to their children, noted the high efficiency of "Creon", calling it "strong", "working", "effective."
Despite a wide range of diagnoses describedusers, this drug has given all the noticeable medical help, eliminating many negative symptoms. Occasionally you can find comments that tell about the absence of any result. This is due to mistakes in the use of drugs (when "Creon" is used instead of "Mezim" before a hospitable meal), with their uncontrolled reception or with an erroneously diagnosed diagnosis.
The difference in cost
If the advantages of pharmacological characteristicsof the preparation "Creon" are obvious, its relative high cost in comparison with enzyme-containing tablets often becomes the reason of refusal of purchase. In terms of availability, which is better, "Creon" or "Mezim Forte" with the same dosage (for example, 10,000 units)? Packaging of 20 tablets "Mezim Forte" in most pharmacies costs in the range of 200-220 rubles, and for an equivalent number of capsules "Creon" the buyer will have to pay about 300-350 rubles. The cost of the same drug, produced by Solway Pharmaceuticals (France) or the German company Abbott Laboratories, with a dosage of 25,000 units (20 capsules) in city and online pharmacies reaches a level of 570-600 rubles. Domestic "Pancreatin" (100 mg) with the same active substance, but less concentration and moderate effect, will cost about 60-70 rubles (60 tablets). Doctors can advise Mikrazim capsules (ABV RUS, Russia), 50 capsules of which cost 466 rubles (10,000 units) or 781 rubles (25,000 units); pills "Pancreatin Forte" ("Biosynthesis", Russia) 20 pieces for 41-50 rubles.
Eventually
Differences in Mezim, Creon and other enzymeThere are quite a few preparations, briefly they can be formulated as follows: gastroresistant capsules with minimocrosses are the most effective form of the drug, helping to direct the active substance into the intestine without changes. The number of pathologies and the degree of their development, in which "Creon" helps, is much more than the indications for Mezim tablets. Practitioners today prefer to recommend innovative capsules "Creon", and only in rare cases, replace it with a budget analogue.
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